eggNOG is a database of nested orthologous gene groups (NOGs) inferred using unsupervised clustering applied to >5,000 complete genomes followed by comprehensive characterization and analysis of the resulting gene families. eggNOG provides orthologous group assignments at 379 different taxonomic levels as well as multiple sequence alignments, maximum-likelihood trees and broad functional annotations for each group accessible via a web interface or through bulk download.
Huerta-Cepas et al., eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses. D1. 2019. PMID: 30418610
Huerta-Cepas et al., eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences. D1. 2016. PMID: 26582926
Powell et al., eggNOG v4.0: nested orthology inference across 3686 organisms. Database issue. 2014. PMID: 24297252
Powell et al., eggNOG v3.0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges. Database issue. 2012. PMID: 22096231
Muller et al., eggNOG v2.0: extending the evolutionary genealogy of genes with enhanced non-supervised orthologous groups, species and functional annotations. Database issue. 2010. PMID: 19900971
Jensen et al., eggNOG: automated construction and annotation of orthologous groups of genes. Database issue. 2008. PMID: 17942413