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Mechismo is a tool that allows rapid predictions of how genetic variants impact on biomolecular function. This is done by a pre-computed collection of protein-protein, protein-DNA/RNA, protein-chemical interactions of known three-dimensional structure mapped to proteomes from major model organisms.  Users can input any number of variants to get a ranked list of genes and specific positions that have a functional impact on biomolecular interactions.

Homepage:

http://mechismo.russelllab.org/

Contact:

Prof. Dr. Rob Russell