This package provides functions and routines for a supervised analysis of somatic signatures. In particular, functions to perform a signature analysis with known signatures (LCD = linear combination decomposition) and a signature analysis on stratified mutational catalogue (SMC = stratify mutational catalogue) are provided.

Homepage

https://bioconductor.org/packages/release/bioc/html/YAPSA.html

Relevant Publications

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification. (2016) Gröschel S, Bommer M, Hutter B, Budczies J, Bonekamp D, Heining C, Horak P, Fröhlich M, Uhrig S, Huebschmann D, Geörg C, Richter D, Pfarr N, Pfütze K, Wolf S, Schirmacher P, Jäger D, von Kalle C, Brors B, Glimm H, Weichert W, Stenzinger A, Fröhling S Cold Spring Harb Mol Case Stud, 2, 6, a001180

Mutant KIT as Imatinib-Sensitive Target in Metastatic Sinonasal Carcinoma. (2016) Dieter SM, Heining C, Agaimy A, Huebschmann D, Bonekamp D, Hutter B, Ehrenberg KR, Fröhlich M, Schlesner M, Scholl C, Schlemmer HP, Wolf S, Mavratzas A, Jung CS, Gröschel S, Kalle CV, Eils R, Brors B, Penzel R, Kriegsmann M, Reuss DE, Schirmacher P, Ann Oncol, pii: mdw446.

Contact

Daniel Huebschmann (This email address is being protected from spambots. You need JavaScript enabled to view it.)

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